|
KMID : 0358819860130040463
|
|
Journal of Korean Society of Plastic and Reconstructive Surgeons
1986 Volume.13 No. 4 p.463 ~ p.469
|
|
|
AN EXPERIMENTAL STUDY ON MAST CELL IN HEALING PROCESS AFTER SKIN INCISION
|
|
Hahn Hyun-Oun
Lee Sae-Il
Lee Da-Ie
|
|
|
Abstract
|
|
|
The mast cells plays a central role in pathophysiology of immunologic or nonimmunologic inflammatory reaction by release of the chemical mediators in their granules. In addition, the mast cells are also probably involved in the healing process of the wound by stimulating proliferation of the fibroblast.
To clarify the role of mast cell in the process of the organization of granulation tissue, experimental incised wound of the skin measuring 1.5cm was given to 15 mice and variation of the number and shape of tissue mast cell in and around the granulation tissue were conuted weekly, 3 mice per week.
The results are followings:
1. The size of granulation tissue after incision of the skin was the largest in wounds at 1st week and subsided at 5th week.
2. There was no mast cell in the granulation tissue at 1st week. They started to appear from 2nd week granulation tissue after incision of the skin and returned to normal level at 5 week.
3. Dermis surrounding the granulation tissue revealed the greatest number of the mast cells at 1st and 2nd weeks after incision of the skin and declined to normal level at 5th week.
Above results showing parallel variation between the size of the granulation tissue and the number of the mast cells around the tissue suggest that the mast cells are involved in the organization of the granulation tissue.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|